Secondly, when a thing is made up of particles, which did all of them before exist, but that very thing so constituted of pre-existing particles, which, considered all together, make up such a collection of simple ideas as had not any existence before; as this man, this egg, rose, or cherry, &c. And this, when referred to a substance, produced in the ordinary course of nature by internal principle, but set on work, and received from some external agent or cause, and working by insensible ways, which we perceive not, we call generation; when the cause is extrinsecal, and the effect produced by a sensible separation, or juxta-position of discernible parts, we call it making; and such are all artificial things. When any simple idea is produced, which was not in that subject before, we call it alteration. Thus a man is generated, a picture made, and either of them altered, when any new sensible quality or simple idea is produced in either of them, which was not there before; and the things thus made to exist, which were not there before, are effects; and those things, which operated to the existence, causes. In which, and all other causes, we may observe, that the notion of cause and effect has its rise from ideas, received by sensation, or reflection; and that this relation, how comprehensible soever, terminates at last in them. For to have the idea of cause and effect, it suffices to consider any simple idea, or substance, as beginning to exist by the operation of some other, without knowing the manner of that operation.